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REVIEW ARTICLE
Year : 2017  |  Volume : 7  |  Issue : 1  |  Page : 8-14

Are statins worthy for treatment of periodontitis? A systematic review and meta-analysis


1 Department of Periodontology, K. M. Shah Dental College and Hospital, Sumandeep Vidyapeeth, Vadodara, Gujarat, India
2 Department of Pediatrics, SBKS Medical Institute and Research Centre, Sumandeep Vidyapeeth, Vadodara, Gujarat, India
3 Department of Medicine, SBKS Medical Institute and Research Centre, Sumandeep Vidyapeeth, Vadodara, Gujarat, India

Correspondence Address:
Monali Shah
Department of Periodontology, K. M. Shah Dental College and Hospital, Sumandeep Vidyapeeth, Pipria, Waghodia, Vadodara, Gujarat
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2321-8568.199531

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Background: Statins are drugs used for locking the synthesis of cholesterol as it inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase. Besides action on cholesterol, statins also possess multiple pleiotropic actions such as anti-inflammatory, immunomodulatory, antioxidant, antithrombotic, angiogenesis promotion and increase in bone formation; other new pleiotropic effects of statins are continuously being described, but their clinical relevance has not been established. Objective: This systematic review and meta-analysis was planned to assess the effect of systemic or local statin therapy on clinical as well as radiographic periodontal parameters in patients with chronic periodontitis. Methodology: A search was performed in the electronic databases of MEDLINE/PubMed, EBSCO and Cochrane databases for randomised controlled trial on humans, and hand search was also carried out. The included articles were screened for their risk of bias and data extracted in predefined format. The meta-analysis was performed using comprehensive meta-analysis. Software: Random effects model was used for pooled analysis. Results: Six studies were included in systematic review having moderate to low risk of bias. Four studies were included in meta-analysis. Results of meta-analysis for clinical parameters such as clinical attachment level (1.95 mm), probing depth (2.28 mm) and marginal sulcular bleeding index (1.10) as well as for radiographic parameters such as intrabony defect (1.90 mm) were statistically significant for locally applied statins. Conclusion: As statins are effective and safe in short-term use and locally delivered and user-friendly, they can be more widely used in periodontal treatment.


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