• Users Online: 1249
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
Year : 2021  |  Volume : 11  |  Issue : 2  |  Page : 147-151

Bacterial protein azurin and tumour suppressor p53 in cancer regression

Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka

Correspondence Address:
Chamindri Witharana
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Colombo, Colombo
Sri Lanka
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/AIHB.AIHB_69_20

Rights and Permissions

Cancer as a cause of frequent illness and death possess a significant threat for the global public health. At a time where the existing conventional therapies such as chemotherapy, radiotherapy, surgery and monoclonal antibodies demand modifications due to their limitations such as toxicity and acquisition of resistance, microbial peptides have revived attention. Azurin is a bacterial cupredoxin secreted by Pseudomonas aeruginosa with the ability of preferential entry and cytotoxicity towards a wide variety of cancer cells in vivo and in vitro. It provides the promise of overcoming resistance due to being a multitargeted anticancer agent showing extracellular mode of action by interaction with several cell surface receptors and intracellular action by interacting with tumour suppressor p53 and interfering in its pathway. Tumour suppressor p53 is frequently mutated in Human cancers and thus the ability of azurin and its peptides to stabilise p53 to revive its functions opens up a revenue of opportunities for exploration in cancer therapeutics. This review aims to discuss about azurin and its peptide p28, the molecule which completed two Phase 1 clinical trials and tumour suppressor p53 for new prospects for the future.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded107    
    Comments [Add]    

Recommend this journal