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REVIEW ARTICLE
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Bacterial protein azurin and tumour suppressor p53 in cancer regression


1 Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka
2 Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka, Sri Lankas

Correspondence Address:
Chamindri Witharana,
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Colombo, Colombo
Sri Lankas
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/AIHB.AIHB_69_20

Cancer as a cause of frequent illness and death possess a significant threat for the global public health. At a time where the existing conventional therapies such as chemotherapy, radiotherapy, surgery and monoclonal antibodies demand modifications due to their limitations such as toxicity and acquisition of resistance, microbial peptides have revived attention. Azurin is a bacterial cupredoxin secreted by Pseudomonas aeruginosa with the ability of preferential entry and cytotoxicity towards a wide variety of cancer cells in vivo and in vitro. It provides the promise of overcoming resistance due to being a multitargeted anticancer agent showing extracellular mode of action by interaction with several cell surface receptors and intracellular action by interacting with tumour suppressor p53 and interfering in its pathway. Tumour suppressor p53 is frequently mutated in Human cancers and thus the ability of azurin and its peptides to stabilise p53 to revive its functions opens up a revenue of opportunities for exploration in cancer therapeutics. This review aims to discuss about azurin and its peptide p28, the molecule which completed two Phase 1 clinical trials and tumour suppressor p53 for new prospects for the future.


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    -  Lakshani Dharmawickreme RB
    -  Witharana C
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